Publications



2020.

Ahel, J., Lehner, A., Vogel, A., Schleiffer, A., Meinhart, A., Haselbach, D., Clausen, T.
Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism
eLife, 2020;9:e56185

Sonn-Segev, A., Belacic, K., Bodrug, T., Young, G., VanderLinden, R. T., Schulman, B.A., Schimpf, J., Friedrich, T., Vinh Dip, P., Schwartz, T.U., Bauer, B., Peters, J.M., Struwe, W.B., Benesch, J.L.P., Brown, N.G., Haselbach, D., Kukura, P.
Quantifying the heterogeneity of macromolecular machines by mass photometry
pdf
Nat Commun. 11: 1772



2019.

Prajapati, S., Haselbach, D., Wittig, S., Patel, MS., Chari, A., Schmidt, C., Stark, H., Tittmann, K.
Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters
pdf

Structure. 27(7):1124-1136.e4

Watson, ER., Grace, CRR., Zhang, W., Miller, DJ., Davidson, IF., Prabu, JR., Yu, S., Bolhuis, DL., Kulko, ET., Vollrath, R., Haselbach, D., Stark, H., Peters, JM., Brown, NG., Sidhu, SS., Schulman, BA.
Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site
pdf

Proc Natl Acad Sci U S A.



2018.

Haselbach, D., Komarov, I., Agafonov, DE., Hartmuth, K., Graf, B., Dybkov, O., Urlaub, H., Kastner, B., Lührmann, R., Stark, H.
Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex
pdf

Cell. 172(3):454-464.e11



2017.

Bertram, K., Agafonov, DE., Dybkov, O., Haselbach, D., Leelaram, MN., Will, CL., Urlaub, H., Kastner, B., Lührmann, R., Stark, H.
Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation
pdf

Cell. 170(4):701-713.e11

Haselbach, D., Schrader, J., Lambrecht, F., Henneberg, F., Chari, A., Stark, H.
Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs
pdf

Nat Commun. 8:15578



2016.

Brown, NG., VanderLinden, R., Watson, ER., Weissmann, F., Ordureau, A., Wu, KP., Zhang, W., Yu, S., Mercredi, PY., Harrison, JS., Davidson, IF., Qiao, R., Lu, Y., Dube, P., Brunner, MR., Grace, CRR., Miller, DJ., Haselbach, D., Jarvis, MA., Yamaguchi, M., Yanishevski, D., Petzold, G., Sidhu, SS., Kuhlman, B., Kirschner, MW., Harper, JW., Peters, JM., Stark, H., Schulman, BA.
Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C
pdf

Cell. 165(6):1440-1453

Qiao, R., Weissmann, F., Yamaguchi, M., Brown, NG., VanderLinden, R., Imre, R., Jarvis, MA., Brunner, MR., Davidson, IF., Litos, G., Haselbach, D., Mechtler, K., Stark, H., Schulman, BA., Peters, JM.
Mechanism of APC/CCDC20 activation by mitotic phosphorylation
pdf

Proc Natl Acad Sci U S A. 113(19):E2570-8

Yamaguchi, M., VanderLinden, R., Weissmann, F., Qiao, R., Dube, P., Brown, NG., Haselbach, D., Zhang, W., Sidhu, SS., Peters, JM., Stark, H., Schulman, BA.
Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation
pdf

Mol Cell. 63(4):593-607



2015.

Chari, A., Haselbach, D., Kirves, JM., Ohmer, J., Paknia, E., Fischer, N., Ganichkin, O., Möller, V., Frye, JJ., Petzold, G., Jarvis, M., Tietzel, M., Grimm, C., Peters, JM., Schulman, BA., Tittmann, K., Markl, J., Fischer, U., Stark, H.
ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space
pdf

Nat Methods. 12(9):859-65



2013.

Dölker, N., Blanchet, CE., Voß, B., Haselbach, D., Kappel, C., Monecke, T., Svergun, DI., Stark, H., Ficner, R., Zachariae, U., Grubmüller, H., Dickmanns, A.
Structural determinants and mechanism of mammalian CRM1 allostery
pdf

Structure. 21(8):1350-60

Monecke, T., Haselbach, D., Voß, B., Russek, A., Neumann, P., Thomson, E., Hurt, E., Zachariae, U., Stark, H., Grubmüller, H., Dickmanns, A., Ficner, R.
Structural basis for cooperativity of CRM1 export complex formation
pdf

Proc Natl Acad Sci U S A. 110(3):960-5



2011.

Köster, DM., Haselbach, D., Lehrach, H., Seitz, H.
A DNAzyme based label-free detection system for miniaturized assays
pdf

Mol Biosyst. 7(10):2882-9